Austin Chih-yu CHEN,Brian Andrew STEARNS,Jason Duarte JACINTHO,Jill Melissa BACCEI,Nicholas Simon STOCK,Ryan Christopher CLARK,Yalda Mostofi BRAVO
申请号：
BR112015013350
公开号：
BR112015013350A2
申请日:
2013.12.10
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
"Triazolone compounds and uses thereof" Summary The invention disclosed herein is directed to compounds of the formula I and pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic cancer, human chronic lymphocytic leukemia, melanoma and other cancers. The invention further comprises pharmaceutical compositions comprising a therapeutically efficient amount of a compound of formula I or a pharmaceutically acceptable salt thereof. The invention disclosed herein also addresses processes for treating prostate, breast, ovarian, liver, kidney, colon, pancreatic cancer, human chronic lymphocytic leukemia, melanoma and other cancers. The invention disclosed herein is further directed to methods of treating prostate, breast, colon, pancreatic, chronic lymphocytic leukemia, melanoma and other cancers comprising administering a therapeutically effective amount of a ppar? selective. The compounds and pharmaceutical compositions of the invention are also useful in the treatment of viral infections, such as hcv infections and hiv infections. 1/1“compostos de triazolona e usos dos mesmos” resumo a invenção divulgada aqui é direcionada a compostos da fórmula i i e sais farmaceuticamente aceitáveis dos mesmos, que são úteis no tratamento de câncer de próstata, mama, cólon, pancreático, leucemia linfocítica crônica humana, melanoma e outros cânceres. a invenção compreende ainda composições farmacêuticas que compreendem uma quantidade terapeuticamente eficiente de composto da fórmula i ou um sal farmaceuticamente aceitável do mesmo. a invenção divulgada aqui também se direciona a processos de tratamento de câncer de próstata, mama, ovariano, fígado, rim, cólon, pancreático, leucemia linfocítica crônica humana, melanoma e outros cânceres. a invenção divulgada aqui é adicionalmente direcionada a processos de tratamento de câncer de próstata, mama, cólon, pancreático, leucemia linfocítica crônica, melanoma e outros cânceres que
