Disclosed is a pharmaceutical composition comprising (a) a bioerodible water insoluble polymer matrix comprising a polyester polymer, wherein the polymer matrix has a melting point of less than 60℃ and (b) an active agent dispersed within the polymer matrix, wherein the composition is formulated to controllably release the active agent for a pre-determined period of time to a target site. Also disclosed are methods of treating a disease or condition with the disclosed compositions.揭露藥學組成物包括(a)包括聚酯聚合物的生物可溶蝕性水不溶性聚合物基質，其中聚合物基質具有小於60℃的熔點及(b)分散於聚合物基質內的活性物質，其中該組成物之配製為在預先設定的一段時間控制釋放活性物質至目標部位。亦揭露以揭露的組成物治療疾病或症狀的方法。
