METHODES DE FABRICATION DE LIGANDS APO-2 A L'AIDE D'IONS METALLIQUES DIVALENTS

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专利权人:

GENENTECH; INC.

发明人:

申请号：

EP00950255.0

公开号：

EP1194555B1

申请日:

2000.06.26

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

Methods of making Apo-2 ligand and formulations of Apo-2 ligand using divalent metal ions are provided. Such divalent metal ions include zinc and cobalt which improve Apo-2 ligand trimer formation and stability. The crystal structure of Apo-2 ligand is also provided, along with Apo-2 ligand variant polypeptides identified using oligonucleotide-directed mutagenesis.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/