Brenda A. KELLOGG BA,Rajeeva SINGH R,Ravi V.J. CHARI RVJ,‧克洛格,‧辛,‧查理
申请号：
HK16104543.6
公开号：
HK1216508A
申请日:
2016.04.20
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
This invention describes a method of conjugating a cell binding agent such as an antibody with an effector group (e.g., a cytotoxic agent) or a reporter group (e.g., a radionuclide), whereby the reporter or effector group is first reacted with a bifunctional linker and the mixture is then used without purification for the conjugation reaction with the cell binding agent. The method described in this invention is advantageous for preparation of stably-linked conjugates of cell binding agents, such as antibodies with effector or reporter groups. This conjugation method provides in high yields conjugates of high purity and homogeneity that are without inter-chain cross-linking and inactivated linker residues.
