Trolox derivative-modified lipophilic anticancer compound, and preparation, production method and use thereof

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专利权人:

チア タイ ティアンチン ファーマシューティカル グループ カンパニー リミテッド

发明人:

ツァン，ユエフア,ツァン,ユエフア

申请号：

JP2014540301

公开号：

JP5782569B2

申请日:

2012.10.18

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

Disclosed is a trolox derivative-modified fat-soluble anti-cancer pharmaceutical compound having a structure as represented by formula I or II. An active moiety of the anti-cancer pharmaceutical compound, camptothecins or a camptothecin derivative, is covalently bonded to a lipophilic moiety, a trolox ester or a trolox amide, by a linking group to form the fat-soluble anti-cancer pharmaceutical compound. Also disclosed are a preparation, preparing method and use of the pharmaceutical compound.

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