Marina Altagracia Martínez,Luis Camilo Ríos Castañeda,Jaime Kravzov Jinich,Maria de los Ángeles Araceli Díaz Ruíz
申请号：
US13266892
公开号：
US20120157541A1
申请日:
2009.10.05
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention aims to demonstrate that a soluble pharmaceutical formulation can be prepared of N,N′-Diamino-diphenyl sulfone which is useful in the development of an ideal drug for use against cerebral infarction, epilepsy, traumatic spinal cord injury, cranio-encephalic trauma, leprosy, Pneumocystis carinii infections and any condition which requires rapid and complete absorption of the compound. As a representative example of this application, the dissolution of N,N′-Diamino-diphenyl sulfone was evaluated as a neuroprotector in a model of acute cerebral infarction in rats. In this study, N,N′-Diamino-diphenyl sulfone showed significant prevention of brain damage, without presenting adverse effects in animals. It is also shown that the soluble pharmaceutical formulations prepared in this manner produce peak blood levels 30 minutes from oral administration and immediately via the intravenous route.
