This document describes the carboxamide derivative that can be used as p90 Ribosomal S6 kinase (RSK) inhibitor, the pharmaceutical composition comprising the derivative, and use derivatives for treatment disease relevant to RSK activity or the method for the patient's condition.This kind of carboxamide derivative forms bicyclic and tricyclic ring system, and disease relevant to RSK activity or the patient's condition described in mammal are cancers.Se describen aquí derivados de carboxamida que son útiles como inhibidores de la quinasa S6 ribosómica p90 (RSK), composiciones farmacéuticas que comprenden los derivados, y métodos para usar los derivados en el tratamiento de enfermedades o condiciones asociadas con la actividad de RSK.
