Aranapakam Mudumbai Venkatesan,Zecheng Chen,Christoph Martin Dehnhardt,Osvaldo Dos Santos,Efren Guillermo Delos Santos,Arie Zask,Jeroen Cunera Verheijen,Joshua Aaron Kaplan,David James Richard,Semiram
申请号：
US14477650
公开号：
US09174963B2
申请日:
2014.09.04
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Compounds of formula Iwherein:R1 isand R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
