Compositions for topical administration to a urogenital area and/or in a vagina are disclosed. The compositions includes a therapeutically effective amount of a selective estrogen receptor modulator (SERM) an intracellular carrier for carrying the SERM into a cell and a therapeutically effective amount of a cellular anti inflammatory agent. Methods for treating atrophic vaginitis peri and post menopausal dyspareunia and/or oopherectomized females prior to menopause by topically applying such compositions to the urogenital area and/or into a vagina are also disclosed.
