David A. Boas;Maria Angela Franceschini;Jason Sutin;ShiNung Ching;Emery N. Brown;Patrick L. Purdon
发明人:
Patrick L. Purdon,Emery N. Brown,ShiNung Ching,David A. Boas,Maria Angela Franceschini,Jason Sutin
申请号：
US14260070
公开号：
US20140316218A1
申请日:
2014.04.23
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Systems and methods for monitoring and/or controlling a brain state of a subject are provided. In certain embodiments, the method includes acquiring physiological data from sensors including electrophysiological sensors and optical sensors, assembling, using data from the electrophysiological sensors, a time-series signal indicative of a brain activity of the subject, and identifying, using the time-series signal, a burst suppression state described by a burst suppression period and a burst period. The method also includes computing, using data from the optical sensors, parameters associated with the burst suppression state, the parameters indicative of least one of a metabolic process and a hemodynamic process, and estimating, using the parameters, time-series signal, and burst period, a response function describing a time course of the parameters correlated with a burst during the burst suppression period. The method further includes controlling a treatment using the response function to generate a target burst suppression state.
