The present invention relates to methods for the preparation of biologically active compounds in nanoparticulate form. The invention also relates to biologically active compounds in nanoparticulate form produced by said methods, to compositions comprising such compounds, to medicaments produced using said biologically active compounds in nanoparticulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of said biologically active compounds administered by way of said medicaments.一種製造奈米微粒形式生物活性化合物之方法，其包含在含有複數個碾磨體之碾磨機中，乾式碾磨一固體生物活性化合物與一可碾磨的研磨化合物之步驟，其持續一段時間足以製造包含生物活性化合物奈米顆粒分散於一至少部分地經碾磨的研磨化合物中之固體分散體。依此所產生的分散於經碾磨的研磨化合物中之奈米微粒狀生物活性化合物可抵抗再凝聚作用。
