THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人:
GEORGIOU, GEORGE,STONE, EVERETT
申请号：
EP09824219
公开号：
EP2350273A4
申请日:
2009.11.02
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
Described are pharmaceutical compositions and medical uses of engineered human arginases, and particularly, among others, a pharmaceutical formulation comprising a protein comprising an amino acid sequence of human Arginase I and a non-native metal cofactor, wherein the non-native metal cofactor is cobalt a pharmaceutical formulation comprising a human Arginase I protein having a metal binding site and comprising at least one amino acid substitution at the metal binding site, wherein the protein displays an increase in the hydrolysis of Arginine that results in a k cat /K m of at least two fold greater than that of a native human Arginase I a pharmaceutical formulation comprising a fusion protein comprising any of the said proteins as well as medical uses related to the above.
