It relates to compositions comprising specific amounts of a hyaluronic acid or a pharmaceutically or veterinary acceptable salt thereof, and two thermoreversible adhesive agents, one of them being a poloxamer, wherein the weight ratio between the poloxamer and the hyaluronic acid or its salt is from 60:1 to 10:1； that may be used as a drug delivery system for the local delivery of active agents to the gastrointestinal tract. It also relates to delivery devices comprising them； and to their uses in medicine, in particular, in the treatment and/or prevention of mucosal lesions； in the prevention of tumor recurrence and reduction of inflammation in the gastrointestinal tract.
