Patient simulation system adapted for interacting with a medicalapparatus, and method for operating the patient simulation system. Aprocessingunit of the patient simulation system stores at least one physiological modelof apatient in a memory of the patient simulation system. The processing unitreceivesat least one gas control parameter from the medical apparatus via acommunication interface of the patient simulation system. The processing unitcorrelates the at least one gas control parameter with one of the at least onephysiological model of a patient to generate simulated physiological effects.Theprocessing unit further transmits the simulated physiological effects to themedicalapparatus via the communication interface. In a particular aspect, the medicalapparatus consists of an anesthesia apparatus.