A method for preventing and/or treating drug-induced renal tissue injury and related diseases thereof of a subject, comprising administering an effective amount of plasminogen to a subject. Also provided are a drug, a pharmaceutical composition, a product, and a kit comprising plasminogen and used for preventing and/or treating drug-induced renal tissue injury and related diseases thereof of the subject.本發明涉及預防和/或治療藥物導致的受試者腎組織損傷及其相關病症的方法,包括給藥受試者有效量的纖溶酶原。本發明還涉及在用於預防和/或治療藥物導致的受試者腎組織損傷及其相關病症的包含纖溶酶原的藥物、藥物組合物、製品、試劑盒。