INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
DIMARCHI, RICHARD D.,戴马志 理察D,戴馬志 理察D,KOU, BINBIN,谷斌斌,谷斌斌
申请号：
TW100121933
公开号：
TW201209062A
申请日:
2011.06.23
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an amide bond linkage. The prodrugs disclosed herein have extended half lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.本發明提供一種胰高血糖素超級家族胜肽之前驅藥設計,其中該胰高血糖素超級家族胜肽係藉由以醯胺鍵結將雙肽連接至胰高血糖素超級家族胜肽而修飾。本發明揭示之前驅藥具有延長之半生期,並於生理環境下透過一非酵素性反應轉換為活化型式,該非酵素性反應係由化學不穩定性驅動。(無元件代表符號)
