Improved, efficient devices/methods for medical and cosmetic applications, involving the delivery of laser energy to tissue are provided. In a preferred embodiment a portable, easy-to-use laser system comprises at least one laser source operating at one or more laser wavelengths an electronic visual display having a n-dimensional input interface to set/select laser parameters and at least one waveguide optically coupled to the laser source to convey laser radiation to a treatment site. The n-dimensional input interface inputs/selects lasing parameters which allows the selection of a combination of output wavelengths and powers by simply touching the electronic visual display. Method of use comprises the steps of placing at least one waveguide at preselected treatment site selecting a combination of laser wavelengths and power by interacting with an electronic visual display and irradiating the treatment site.