The subject matter of the invention is the use of a substituted or non- substituted hydroxyapatite particle as a carrier of bioactive molecules for the prevention and treatment of grapevine trunk disease, in particular esca disease of the vines. In a preferred embodiment the hydroxyapatite is substituted by at least one carbonate ion, corresponding to the formula: Ca(10)(P04)(6-y)(C03)y(OH)2 wherein y is a number comprised between 0.002 and 0.030, and having a crystallinity degree comprised between 25 and 59 %. The invention also covers aggregates of these particles and compositions including these particles or aggregates.
