Compositions comprising serum albumin and p53 peptides fusion proteins

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专利权人:

University of the Sciences of Philadelphia

发明人:

Zhiyu Li,Michelle Parker

申请号：

US14948010

公开号：

US10053498B2

申请日:

2015.11.20

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention relates to compositions useful in inhibiting Bcl-XL or MCL-1 and disrupting p53-MDM2 and p53-MDMX interactions, and methods of using those compositions for treating a subject for conditions responsive to increasing p53 mediated activity or promoting p53 independent apoptosis, such as treating cancer. In some aspects, the compositions of this invention relate to fusion polypeptides comprising a human serum polypeptide and a p53-peptide, which can be, in some aspects, a p53 derived peptide and/or a p53 activating peptide.

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