WENG, CHING FENG,翁庆丰,翁慶豐,CHIA, YI CHEN,贾宜琛,賈宜琛,WU, CHIA JEN,吴嘉仁,吳嘉仁,TSAI, HSIANG I,蔡湘仪,蔡湘儀
申请号：
TW102145811
公开号：
TW201519897A
申请日:
2013.12.12
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
The present invention is related to a method for liver fibrosis prevention and/or treatment and a pharmaceutical composition thereof. The method and the pharmaceutical composition are made by taking the advantage of Blumea lacera ‘efficacy in accumulating lipid in hepatic stellate cells, down-regulating the proliferation of hepatic stellate cells, inhibiting the mobility of hepatic stellate cells, preventing the activation of hepatic stellate cells, and decreasing the synthesis of ECM proteins. The present invention not only provides a novel optional for clinical prevention and treatment of liver fibrosis, but also promotes the industrial value of Blumea lacera.本發明關於一種預防及/或治療肝纖維化的方法及其相關之醫藥組合物。該方法及該醫藥組合物是利用生毛將軍於肝星狀細胞中累積脂質、負調控肝星狀細胞的增生、抑制肝星狀細胞的移動、避免肝星狀細胞的活化、及降低細胞外基質(ECM)蛋白質的生成的效果。本發明不僅提供臨床上預防及治療肝纖維化的新穎選擇，更提升了生毛將軍的產業價值。
