This disclosure describes, among other things, methods, devices, and systems for non-invasive evaluation of a patients vascular system and custom design and manufacture of one or more components of a delivery device for delivery and deployment of an implantable medical device, such as a prosthetic heart valve. For example, a delivery sheath can be 3D printed to have varying durometers at one or more areas along its length and/or circumference so that it can more easily bend and flex as it traverses particularly tortuous anatomical features.
