Samuel RAHBAR,James L. FIGAROLA,Christopher LINCOLN,David HORNE,Rachael MOONEY,Monika POLEWSKI,George SOMLO,Lixin YANG
申请号：
US13953013
公开号：
US20140162996A1
申请日:
2013.07.29
申请国别(地区):
US
年份:
2014
代理人:
摘要：
One aspect of the disclosure relates to derivatives of aryl and heterocyclic ureido aryl and heterocyclic carboxamido isobutyric acids, dichlorophenyl urea, curcumin, and 1,3-diazetidine-2,4-dione, and pharmaceutical compositions thereof. The derivatives disclosed herein can modulate development of adipocytes and various cancer cells, including resistant cancer cells and cancer stem cells. Another aspect of the disclosure relates to the use of the derivatives and pharmaceutical compositions disclosed herein in treatment of obesity and various cancers.
