LAW, Yuen Kwan,WU, An-Guo,WONG, Kam Wai,LIU, Liang
申请号：
AU2014101057
公开号：
AU2014101057A4
申请日:
2014.09.02
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
#$%^&*AU2014101057A420141002.pdf#####ABSTRACT An active autophagic fraction derived and isolated from Radix Polygalae as a novel autophagy enhancer, and a method of preventing, treating and/or delaying the onset of neurodegenerative disease comprising administering a pharmaceutical composition comprising said active autophagic fraction are provided in the present invention. Said active autophagic fraction exhibits the neuroprotective function through accelerating the clearance of mutant huntingtin and A53T alpha-synuclein, and autophagic effect which is dependent on the presence of autophagy-related gene 7. In the present invention, at least seventeen active compounds have been identified from said active autophagic fraction, which possess neuroprotective activities. Said neurodegenerative diseases comprise Parkinson's disease and Huntington's diseaseSheet 1/10 .......... .opnet -no-- aim[ns S ~ -W5 , PIt 0~ 2,5.- 5,0 7, O1. 1 , 0 25 M 0 25 5 5W 1 M 1 2 25 m ii Figure 1
