MODIFICATION CRISTALLINE DE 2-(3,5-BIS-TRIFLUOROMETHYL-PHENYL)-N-[6-1,1-DIOXO-1.LAMBDA.6-THIOMORPHOLIN-4-YL)-4(4-FLUORO-2-METHYL-PHENYL)-PYRIDIN-3-YL]-N-METHYL-ISOBUTYRAMIDE
HOFFMANN, TORSTEN,HOFFMANN-EMERY, FABIENNE,NICK, SONIA,SCHWITTER, URS,WALDMEIER, PIUS
申请号：
CA2514037
公开号：
CA2514037C
申请日:
2004.01.23
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to a new crystalline modification of 2-(3,5-bis-trifluoromethyl-phenyl)-N-[6-(1,1-dioxo-1.lambda.6-thiomorpholin-4-yl)-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide characterized by the following X-raydiffraction pattern obtained with a Cu K.alpha. radiation at 2.theta. (2Theta)= 4.5, 6.4, 7.5, 7.7, 8.0,8.2, 10.0, 10.2, 10.9, 11.1, 12.9, 13.4, 14.0, 14.5, 15.1, 15.6, 16.2, 16.5,17.3, 17.5, 18.0,18.9, 19.3, 19.5, 19.9, 20.1, 20.6, 21.0, 21.4, 22.7, 23.1 and 23.6 and aninfraredspectrum having sharp bands at 2925, 2854, 1637, 1604, 1484, 1395, 1375, 1285,1230,1172, 1125, 1082, 999, 943, 893, 868, 860, 782, 705, 684 cm -1, and whereintheextrapolated melting point (DSC) is 137.2°C.
