一種結合BCMA的嵌合抗原受體(CAR)及其應用农业专利-农业专业知识服务系统

专利权人:: NANJING IASO BIOTHERAPEUTICS CO., LTD.;INNOVENT BIOLOGICS (SUZHOU) CO., LTD.

发明人:: ZHOU, JIANFENG,周剑峰,周劍峰,LIU, JUNJIAN,刘　军建,劉　軍建,HU, GUANG,胡广,胡廣,YANG, YONGKUN,杨永坤,楊永坤,MENG, GUANGRONG,孟广荣,孟廣榮,GAO, WENJING,高文静,高文靜,WANG, YUYU,王玉玉,NIU, PANPAN,牛盼盼

摘要：: The present application relates to a chimeric antigen receptor (CAR) that can specifically bind to a BCMA protein, comprising a BCMA binding domain, a transmembrane domain, a costimulatory domain, and an intracellular signaling domain. The application also provides a use of the CAR in the treatment of a disease or condition associated to the expression of BCMA.本申請涉及一種可以特異性結合BCMA蛋白的嵌合抗原受體(CAR)，其包含BCMA結合結構域、跨膜結構域、共刺激結構域和胞內信號傳導結構域。本申請還提供了該CAR在用於治療與BCMA的表達相關的疾病或病症中的應用。