Agnieszka Seyda,David C. Colter,Charito S. Buensuceso,Christian C. Kazanecki,Sridevi Dhanaraj
申请号:
US13765008
公开号:
US20130209418A1
申请日:
2013.02.12
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Methods and therapeutics are provided for treating diseases, including metabolic diseases and other weight-related disorders. Generally, methods for making brown adipose-like including culturing a population of artery-derived cells in adipogenic induction medium for a period of time and under conditions sufficient to increase expression of at least one adipocyte marker at a higher level as compared to untreated artery-derived cells are disclosed. Isolated artery-derived, ex vivo differentiated brown adipose-like cells are also provided, including pharmaceutical compositions and cell delivery systems thereof. In another embodiment, a method of treating a subject is disclosed that includes obtaining a population of artery-derived brown adipose-like cells and administering the brown adipose-like cells into a target region in the subject.