The present disclosure describes ultrasound imaging systems and methods that may be used to image breast tissue. An ultrasound imaging system according to one embodiment may include a user interface comprising a display, a processor operatively connected to the user interface, and memory comprising processor-executable instructions, which when executed by the processor cause the user interface to display a first ultrasound image of a breast on the display and receive an indication of a first region of interest (ROI) in the first ultrasound image. The memory may include instructions to further cause the user interface to display a second ultrasound image of the breast on the display and receive an indication of a second region of interest in the second ultrasound image. The processor may be configured to determine locations of the first and second regions of interest based on probe position data associated with the first and second images, respectively and cause the user interface to display a visual indication of a relative distance between the first and second regions of interest if the relative distance is less than or equal to a predetermined amount.
