Wuxi Kingenew Biotechnology Limited Company;BEIJING GEFUCURE BIOTECHNOLOGY LIMITED COMPANY
发明人:
Bo Tang,Ran Zhang,Jianmin Zhao,Jianwu Wang,Yunping Dai
申请号：
US16345648
公开号：
US20200270358A1
申请日:
2017.07.24
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided is an afucosylated monoclonal antibody. The monoclonal antibody is a human IgG antibody and has an afucosylated sugar chain structure at a heavy-chain sugar chain binding site. Also provided are application of the monoclonal antibody in the preparation of antineoplastic drugs, and a composition containing the monoclonal antibody. Compared with a fucosylated monoclonal antibody, the provided afucosylated monoclonal antibody has higher biological activity in vitro and in vivo and can be used for developing more effective therapeutic monoclonal antibody drugs.
