DONG, ZHENG XIN,PRAIRIE, NICHOLAS C.,UFRET, MARIA L.,ZHANG, JUNDONG,ROTHMAN, DEBORAH,COMSTOCK, JEANNE MARY
申请号：
CA2768621
公开号：
CA2768621C
申请日:
2010.07.22
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to novel analogues of insulin-like growth factor- 1 (IGF- 1), pharmaceutical compositions containing said analogues, and the use of said analogues for treatment of IGF-1 -receptor mediated conditions, such as short stature, diabetes therapy, neurodegenerative disease treatment, and cartilage repair. More particularly, the present invention relates to novel analogues of IGF-I having an amino acid substitution at position 59, e.g., (Asn59)hIGF- 1(1 -7O)-OH (SEQ ID NO: 1), and other substitution(s) as defined herein.
