Pharmaceutical compositions comprising advanced glycosylation end product degraders (ages) and adjuvant drugs such as antihypertensive, antidiabetic drugs and the like.
The present invention relates to a combination, such as a combined preparation or pharmaceutical composition comprising: (a) compound of formula (I), and/or (II) or a pharmaceutically acceptable salt thereof； (b) at least one therapeutic agent selected from the group consisting of: an antihypertensive agent； an antidiabetics agent； a hypolipidemic agent； an antiplatelet agent； an antiobesity agent； an antithrombotic agent； an agent for diabetic vascular complications； and an agent for treatment of heart failure； or a pharmaceutically acceptable salts thereof, optionally in presence of a pharmaceutically acceptable carrier for separate, simultaneous or sequential use. The present invention also relates to a use of such combination for the treatment of mammal including human being. R 1 , R 2 , R 3 , R 1 , R 2 , R 3 , R 4 , R 5 , X, Y, A and B and m are as defined in the specification.
