Pere Joan Cardona Iglesias,Isabel Amat Riera,Blanca Reyes Moreno,Maria Mercè Amat Fabregat
申请号：
US14371613
公开号：
US09682042B2
申请日:
2012.01.12
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention relates to an agent for the treatment or prevention of an allergic condition, such as asthma, in a mammal. The agent comprises fragments of a Mycobacterium tuberculosis-complex (MTB-C) strain. These particular fragments may be from a virulent MTB-C strain and/or in the form of a liposome composition. The agent may include further components, such as a liposome-forming agent and/or particular proteins from the MTB-C strain.A particular allergic response that may be treated by the agent of the invention is allergic asthma. A pharmaceutical composition comprising the agent is also provided.Administration of the agent described herein significantly attenuates airway hyperresponsiveness, eosinophilia and lymphocytosis in the airways of sensitized animals. The effectiveness of the agent exceeds on all the evaluated parameters the commercial vaccine BCG Danish 1331 Strain.
