Patrick A. McKee,Kenneth W. Jackson,Victoria J. Christiansen
申请号：
US15602709
公开号：
US10155789B2
申请日:
2017.05.23
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Inhibitors of fibroblast activation protein alpha (FAP) and Prolyl Oligopeptidase (POP) are disclosed, along with their use in various therapies related to conditions, diseases, and disorders involving abnormal cell proliferation such as malignancies and angiogenesis, and in neural disorders such as Alzheimers disease. Stalk portions of the inhibitor molecules, and substrates of FAP and POP, are also disclosed and may be used, for example, in screening methods for identifying such inhibitors.
