The methods using associated formulations for intra-articular local delivery to treat an afflicted joint, for example, to treat osteoarthritis. Some methods deliver anti-inflammatory agents and angiogenesis inhibitors, and can include sensitizing agents for one or both. Formulations can include hyaluronic acid, a therapeutic solvent, and drug micro or nanoparticles, which may be formed of drug alone or in combination with an excipient or polymeric carrier. The carrier can include hydrophobic sugar nano-particles, which can resist degradation and provide extended cushioning. The excipient or polymer can be used to manipulate release rates and to increase drug retention to the affected region.
