ALONSO JORGE,ENCINAS LOPES ARANTXA,MUELBAIER MARCEL,AMMENN JOCHEN,WENDT BERND,LEWIS JOE,SCHULTES CHRISTOPH,JANSSEN BERND
申请号：
IN4598/CHENP/2011
公开号：
IN2011CN04598A
申请日:
2011.06.28
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
The present invention provides novel compounds that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)- mediated transcription and signaling under hypoxic conditions. In one aspect, the compounds of the present invention are useful for the preparation of a medicament for the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularisation. Also provided is a pharmaceutical composition comprising a compound of the invention and a second therapeutic agent or radiation useful for the treatment or prevention of the mentioned diseases or disorders. In a first aspect the present invention relates to a compound having a structure according to formula (I).
