VAN AERSCHOT, ARTHUR,HERDEWIJN, PIET,LAGOJA, IRENE,PANNECOUCQUE, CHRISTOPHE,DE CLERCQ, ERIK
申请号：
DK01919343
公开号：
DK1370539T3
申请日:
2001.02.23
申请国别(地区):
DK
年份:
2012
代理人:
摘要：
An N-aminoimidazole or N-aminoimidazolethione derivative, a pharmaceutically acceptable salt, a tautomer, an isomer, an ester or glycosylation product thereof, said derivative being represented by general formula (I): wherein m=zero or 1, n=zero or 1, R<；SUP>；1 <；/SUP>；is selected from hydrogen, methyl or ethyl, R<；SUP>；2 <；/SUP>；is selected from hydrogen, SH or -SR<；SUP>；0 <；/SUP>；wherein R<；SUP>；0 <；/SUP>；is methyl, benzyl or glucose residue； Q is selected from 1-naphtyl, 2-naphtyl, biphenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, thienyl, or a substituted or unsubstituted phenyl ring, wherein the substitution is understood as being one or two substituents selected from H, F, Cl, Br, I, methyl, ethyl or isopropyl； L is selected from 1-naphtyl, 2-naphtyl, biphenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, thienyl, or a substituted or unsubstituted phenyl ring wherein the substitution is understood as being one or two substituents selected from H, F, Cl, Br, I, methyl, ethyl or isopropyl. This invention further relates to the use of compounds of formula (I) as agents having biological activity, especially against viral infections.
