アルドラーゼ、それらをコードする核酸ならびにそれらの作製および使用方法
- 专利权人:
- 发明人:
- 申请号：
- JP20120225075
- 公开号：
- JP5793487(B2)
- 申请日:
- 2012.10.10
- 申请国别(地区):
- 日本
- 年份:
- 2015
- 代理人:
- 摘要：
This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as ce
- 来源网站：
- 中国工程科技知识中心
