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Process and intermediates for the preparation of 5-biphenyl-4-yl-2-methylpentanoic acid derivatives
专利权人:
NOVARTIS AG
发明人:
HOOK, DAVID,RISS, BERNHARD,KAUFMANN, DANIEL,NAPP, MATTHIAS,BAPPERT, ERHARD,POLLEUX, PHILIPPE,MEDLOCK, JONATHAN,ZANOTTI-GEROSA, ANTONIO
申请号:
NZ60011909
公开号:
NZ600119A
申请日:
2009.01.16
申请国别(地区):
NZ
年份:
2013
代理人:
摘要:
600119 Disclosed are process for preparing a compound of formula (3) which is 5-Biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one. An example of the process includes reacting a compound of formula 5 (5-Biphenyl-4-ylmethyl-3-hydroxymethyl-pyrrolidin-2-one) to form a compound of formula 12 (such as 5-Biphenyl-4-ylmethyl-3-iodomethyl-pyrrolidin-2-one) and then reducing it to a compound of formula (3). Also disclosed is a compound prepared by the processes.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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