Process and intermediates for the preparation of 5-biphenyl-4-yl-2-methylpentanoic acid derivatives

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专利权人:

NOVARTIS AG

发明人:

HOOK, DAVID,RISS, BERNHARD,KAUFMANN, DANIEL,NAPP, MATTHIAS,BAPPERT, ERHARD,POLLEUX, PHILIPPE,MEDLOCK, JONATHAN,ZANOTTI-GEROSA, ANTONIO

申请号：

NZ60011909

公开号：

NZ600119A

申请日:

2009.01.16

申请国别(地区):

NZ

年份:

2013

代理人:

摘要：

600119 Disclosed are process for preparing a compound of formula (3) which is 5-Biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one. An example of the process includes reacting a compound of formula 5 (5-Biphenyl-4-ylmethyl-3-hydroxymethyl-pyrrolidin-2-one) to form a compound of formula 12 (such as 5-Biphenyl-4-ylmethyl-3-iodomethyl-pyrrolidin-2-one) and then reducing it to a compound of formula (3). Also disclosed is a compound prepared by the processes.

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