ФОРУД Бехроуз Брюс (US),ГХОШ Соумитра С. (US),ТРЕВАСКИС Джеймс Л. (US),СУНЬ Чэнцзао (US)
申请号：
RU2012126101/10
公开号：
RU2012126101A
申请日:
2010.11.23
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A polypeptide conjugate comprising Compound 1A or compound 2A.2. The polypeptide conjugate of claim 1, comprising a compound 1A.3. The polypeptide conjugate of claim 1, comprising a compound 2A.4. The polypeptide conjugate according to any one of claims 1-3, wherein compound 1A or 2A compound is covalently bound to at least one polyethylene glycol moiety, at least one fatty acid, or albumin poliaminokislotoy.5. A compound according to any one of claims 1-4 in a pharmaceutically acceptable soli.6. A pharmaceutical composition comprising a polypeptide conjugate according to any of claims 1-5 and a pharmaceutically acceptable nositel.7. A method of treating diabetes in a subject having such a need or desire, comprising administering a therapeutically effective amount of the polypeptide conjugate or the pharmaceutical composition according to any one of claims 1-6 for the treatment of diabetes in subekta.8. A method according to claim 7, wherein diabetes is type 1 diabetes tipa.9. A method according to claim 7, wherein diabetes is diabetes tipa.10 2. A method according to claim 9 in the case where the subject is overweight, obese or propensity to overweight or ozhireniyu.11. A method for treating insulin resistance, treatment of postprandial hyperglycemia, reducing blood glucose levels, reduction in HbA1c levels, stimulate insulin secretion, reduce gastric motility, delay gastric emptying, decrease food intake, reducing body weight, treatment of overweight and / or obesity treatment, a subject having such a need or desire, comprising administering a therapeutically effective amount of the polypeptide conjugate or the pharmaceutical composition according to any one of claims 1-61. Полипептидный конъюгат, содержащий соединение 1A или соединение 2A.2. Полипептидный конъюгат по п.1, содержащий соединение 1A.3. Полипептидный конъюгат по п.1, содержащий соединение 2A.4. Полипептидный конъюгат по любому из пп.1-3, в котором соединение 1A или соединение 2A ковалентно связано
