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АНТИТЕЛА ДЛЯ ЛЕЧЕНИЯ АССОЦИИРОВАННОЙ С Clostridium difficile ИНФЕКЦИИ И ЗАБОЛЕВАНИЯ
专利权人:
ПРОДЖИНИКС ФАРМАСЬЮТИКАЛС; ИНК. (US)
发明人:
МА Дангше (US),НАГАШИМА Кирстен (US),КЕННЕДИ Брайан (US),ДОНОВАН Джералд П. (US),КАНГ Юн (US),ОЛСОН Уильям С. (US),КУМАР Шанкар (US),ТСУРУШИТА Наойа (US),МАРОЗСАН Андре Дж. (US),КУПО Альберт (US)
申请号:
RU2012143837/10
公开号:
RU2012143837A
申请日:
2011.04.15
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. An isolated antibody or antigen binding fragment thereof which (a) specifically binds C. difficile toxin A and which crosshair competes for binding to C. difficile toxin A monoclonal antibody produced by the hybridoma cell line deposited under the access № ATCC PTA-9692, PTA-9694 or PTA-9888, and / or that (b) specifically binds to C. difficile toxin a epitope defined by monoclonal antibody produced by the hybridoma cell line deposited under the access № ATCC PTA-9692, PTA-9694 or PTA-9888.2 . The antibody or antigen-binding fragment of claim 1, wherein the monoclonal antibody or antigen-binding fragment is a chimeric or humanized forme.3. The isolated antibody or antigen binding fragment thereof which (a) specifically binds C. difficile toxin B, and which cross-competes for binding to C. difficile toxin B with a monoclonal antibody produced by the hybridoma cell line deposited under the access № ATCC PTA-9693 and / or which (b) specifically binds to C. difficile toxin in an epitope defined by a monoclonal antibody produced by the hybridoma cell line deposited under the access № ATCC PTA-9693.4. The antibody or antigen-binding fragment of claim 3, wherein the monoclonal antibody or antigen-binding fragment is a chimeric or humanized forme.5. Monoclonal antibody RA-39 (№ access ATCC PTA-9692) or antigen-binding fragment.6. Monoclonal antibody RA-50 (№ access ATCC PTA-9694) or antigen-binding fragment.7. Monoclonal antibody RA-38 (№ access ATCC PTA-9888) or a antigenevyazyvayuschy fragment.8. Monoklonal
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