Provided herein are, inter alia, compositions and methods for the treatment of cancer and inhibition of metastasis. The compositions include a μ-opioid receptor (MOR) polypeptide and a somatostatin receptor 2 (SSTR2) polypeptide, wherein the MOR polypeptide is bound to a MOR antagonist and the SSTR2 polypeptide is bound to a SSTR2 antagonist. The compositions and methods provided herein are, inter alia, useful to treat pancreatic cancer.