A catheter assembly is described for providing image-guided therapy in a patients vasculature. The distal end of an elongated catheter body, having a tubular lumen wall, is adapted for insertion into and operation within a patients vasculature while a proximal portion remains outside said patient. An outwardly-facing set of RF electrodes and a distal-facing array of ultrasound imaging transducers are contained within the distal end of the catheter, proximal to one another. The RF electrodes are configured to transmit and receive ultrasound pulses through the ultrasound transducers, providing real-time imaging information of plaque which may be ablated by said electrodes. The RF conductive lines connected to the RF electrodes extend longitudinally through the lumen wall of the catheter body, while coaxial conductive lines, operatively connected to the ultrasound imaging transducers, extend longitudinally through the lumen of the catheter body.
