Tom Louis Dirk Gheysens;David Philip Knight;Andrew Michael Collins;Christopher Holland;Nicholas James Vavasour Skaer
发明人:
David Philip Knight,Nicholas James Vavasour Skaer,Andrew Michael Collins,Tom Louis Dirk Gheysens,Christopher Holland
申请号：
US12990399
公开号：
US08128984B2
申请日:
2009.04.30
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A method for the preparation of a regenerated silk fibroin solution comprises the steps of: treating silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between −0.001 and −0.05 at 25° C.； and subsequently degumming the treated silk or silk cocoons； or alternatively, degumming silk or silk cocoons； and subsequently treating the degummed silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between −0.001 and −0.05 at 25° C. The invention also extends to fibroin solution, a fibroin material and an implant useful for cartilage repair.
