JONES, ALISON,KEMP, MARK IAN,STOCKLEY, MARTIN LEE,GIBSON, KARL RICHARD,WHITLOCK, GAVIN ALISTAIR,MADIN, ANDREW
申请号：
CA2958262
公开号：
CA2958262A1
申请日:
2015.09.22
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.
