PROBLEM TO BE SOLVED: To provide a medicine which is high in safety, has a sufficiently strong action for inhibiting the production of an inflammatory cytokine, TNF-&alpha, and is useful as an anti-inflammatory agent and the like.SOLUTION: This TNF-&alpha production inhibitor in animal cells is characterized by containing a compound represented by formula (1) as an active ingredient. The compound represented by formula (1) inhibits the production of the TNF-&alpha, the production of inflammatory cytokines such as IL-6 and IL-1&beta, and further the production of nitrogen monoxide (NO) in animal cells.COPYRIGHT: (C)2008,JPO&INPIT【課題】安全性が高く、TNF-αなどの炎症性サイトカインであるTNF-αの産生抑制作用が十分に強く、抗炎症剤等として有用な新規な薬剤を提供する。【解決手段】下記式(1)で示される化合物を活性成分として含有することを特徴とする動物細胞におけるTNF-α産生抑制剤。【化1】
