The present invention provides a photosensitizing composition for treatment ofMRSA comprising a photosensitizerand chlorhexidine and a pharmaceutically acceptable carrier. The presentinvention also provides a method for reducing diseasecausing microbes comprising: applying the composition comprising a photosensitizer, chlorhexidine at a concentration of morethan about 0.01% and less than about 2% v/v, and a pharmaceutically acceptablecarrier to a treatment site and applying light tothe treatment site at a wavelength absorbed by the photosensitizer so as toreduce the microbes at the treatment site.
