Endoluminal treatment devices and methods are provided. Generally, the device and methods can allow an endoluminal device to be introduced into a lumen of a patient and engage a wall of the lumen with an implant device, which can be a drug delivery device or medical device. In one embodiment, a medical implant apparatus is provided that includes an anchor object configured to couple with tissue, and an adjustable mechanism configured to interact with the anchor object such as to apply alternative forces upon the anchor object in response to a stimulus.