Meghan Drummond Samuelson,Brian Zambrowicz,Ka-Man Venus Lai,Charleen Hunt,Susannah Brydges,Andrew J. Murphy,Claudia Gonzaga-Jauregui,Jose Rojas,Nicole Alessandri-Haber,Robert Breese,Susan D. Croll
申请号：
US16744493
公开号：
US20200229409A1
申请日:
2020.01.16
申请国别(地区):
US
年份:
2020
代理人:
摘要：
This disclosure relates to an animal model of human disease. More specifically, this disclosure relates to a rodent model of mood disorders such as unipolar depression and an anxiety disorder. Disclosed herein are genetically modified rodent animals that carry a humanized G protein-coupled receptor 156 (GPR156) gene that encodes a mutant human GPR156 protein comprising Asp at an amino acid position corresponding to position 533 in a full length wild type human GPR156 protein.
