This invention disclosed the use of acetyl L-carnitine or of a pharmaceutically acceptable salt thereof for the preparation of a medicament for preventing and/or treating peripheral neuropathies induced by the administration of a peripheral neuropathy - inducing anticancer agent. In particular said anticancer agent is selected from the group consisting of the family of platin compounds, taxanes, epothilone class and vinca alkaloids, farnesyl transferase inhibitors, thalidomide, 5-fluorouracil, cryptophycin analogues, proteasome inhibitors. Said medicament can be administered in a co-ordinated manner to a subject suffering from said peripheral neuropathies, or expected to suffer from said peripheral neuropathies. Beneficial effects on the patient's quality of life are achieved and an improvement of therapeutic index of the anticancer agent is obtained.本發明揭示乙醯基L-肉毒鹼或其醫藥上可接受之鹽用於製備藥物之應用，該藥物係用以預防及/或治療因為服用末稍神經病變誘發性抗癌劑所誘發之末稍神經病變。該抗癌劑特別是選自鉑化合物家族、紫杉烷(taxane)、伊波提酮(epothilone)類及長春花生物鹼、法呢基轉移酶抑制劑、酞胺哌啶酮、5-氟尿嘧啶、隱藻素同質物、蛋白酶體抑制劑。該藥物可共同投藥於患有該末稍神經病變或可能患有該末稍神經病變之患者。改善患者生活品質且改善抗癌劑之治療指數。
