БАГИ Седо Мартин (US),ЧАЙЛДЕРС Тедд Алан (US),ДОМИНОУСКИ Пол Джозеф (US),КРЕБС Ричард Ли (US),МАННАН Рамасами Маннар (US),ОЛСЕН Мэри Кэтрин (US),ТОМПСОН Джеймс Ричард (US),УИРАТНА Рисини Даммика (CA)
申请号：
RU2010149495/15
公开号：
RU2010149495A
申请日:
2009.06.24
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. An immunogenic composition comprising an adjuvant composition and an immunologically effective amount of an antigenic component, wherein the adjuvant composition contains saponin, sterol, a quaternary ammonium compound, a polymer, and optionally a Th2 stimulant. ! 2. The method of preparation of the immunogenic composition according to claim 1, wherein:! a) prepare the composition of the antigenic component in the buffer； ! b) add saponin to the composition from step (a)； ! c) sterol is added to the composition from step (b)； ! d) add a quaternary ammonium compound to the composition of step (c)； ! d) add the polymer to the composition from stage (g)； and! e) optionally a Th2 stimulant is added to the composition from step (e). ! 3. A vaccine composition comprising an adjuvant composition and a therapeutically effective amount of an antigenic component, wherein the adjuvant composition contains saponin, sterol, a quaternary ammonium compound, a polymer, and optionally a Th2 stimulant. ! 4. The composition according to claim 1 or 3, wherein the saponin is Quil A or a purified fraction thereof, the sterol is cholesterol, the quaternary ammonium compound is dimethyldioctadecylammonium bromide (DDA), the polymer is polyacrylic acid, and the Th2 stimulator is glycolipid. ! 5. The composition according to any one of claims 1 or 3, further comprising oil. ! 6. A method of preparing a vaccine composition according to claim 3, wherein:! a) prepare the composition of the antigenic component in the buffer； ! b) add saponin to the composition from step (a)； ! c) sterol is added to the composition from step (b)； ! d) add a quaternary ammonium compound to the composition of step (c)； ! d) add the polymer to the composition1. Иммуногенная композиция, содержащая адъювантную композицию и иммунологически эффективное количество антигенного компонента, где адъювантная композиция содержит сапонин, стерол, четвертичное аммониевое соединение, полимер и возможно стимулятор Th2. ! 2. Сп
