A system and methods for molecular breast imaging (MBI) using pixelated gamma cameras provide easier patient positioning and biopsy access using compression paddles and movable gamma cameras. The paddles and cameras can be curved to better conform to the breast shape. A variable-angle slant-hole collimator is provided to assist in stereotactic imaging for biopsy guidance. Methods for performing an MBI screening or diagnostic examination and guiding a biopsy with stereotactic MBI are provided.
